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Article

Non-cytomembrane PD-L1: An atypical target for cancer

24 Jun 2021

Abstract excerpt

Programmed death ligand 1 (PD-L1) has conventionally been considered as a type I transmembrane protein that can interact with its receptor, programmed cell death 1 (PD-1), thus inducing T cell deactivation and immune escape. However, targeting the PD-1/PD-L1 axis has achieved adequate clinical responses in very few specific malignancies. Recent studies have explored the extracellularly and subcellularly located...

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PMID: 34174446
DOI: 10.1016/j.phrs.2021.105741

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