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Article

Hierarchy of membrane-targeting signals of phospholipase D1 involving lipid modification of a pleckstrin homology domain.

The Journal of biological chemistry - 9 Aug 2002

Sugars Jane M, Cellek Selim, Manifava Maria, Coadwell John, Ktistakis Nicholas T

Abstract excerpt

The amino terminus of phospholipase D1 (PLD1) contains three potential membrane-interacting determinants: a phox homology (PX) domain, a pleckstrin homology (PH) domain and two adjacent cysteines at positions 240 and 241 within the PH domain that are fatty acylated in vivo. To understand how these determinants contribute to membrane localization, we have mutagenized critical residues of the PLD1 PH domain in the...

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Identifiers

PMID: 12021265
DOI: 10.1074/jbc.M112169200

Genes

PLD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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