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Article

Identifying key residues of sphinganine-1-phosphate lyase for function in vivo and in vitro.

The Journal of biological chemistry - 18 Jul 2008

Mukhopadhyay Debdyuti, Howell Kate S, Riezman Howard, Capitani Guido

Abstract excerpt

Sphinganine-1-phosphate lyase (Dpl1p) is a highly conserved enzyme of sphingolipid metabolism that catalyzes the irreversible degradation of sphingoid base phosphates, which are potent signaling molecules. Sphingoid base phosphates play a vital role in cell survival, proliferation, migration, heat stress, and cell wall integrity pathways. Little is known about the structure and regulation of Dpl1p. In this study,...

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PMID: 18487605
DOI: 10.1074/jbc.M709753200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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