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Article

Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain.

PloS one - 1 Jan 2013

Kumar Ambuj, Purohit Rituraj

Abstract excerpt

BACKGROUND: AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the most frequently activated proliferated and survival pathway of cancer. Recently it has been shown that E17K mutation in the Pleckstrin Homology (PH) domain of AKT1 protein leads to cancer by amplifying the phosphorylation and membrane localization of protein. The mutant has shown resistance to AKT1/2 inhibitor VIII drug...

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Identifiers

PMID: 23741320
DOI: 10.1371/journal.pone.0064364
PMCID: PMC3669323

Genes

AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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