Article

The effect of phosphatidylserine on the membrane insertion of the cancer-targeting ATRAM peptide is defined by the non-inserting end

2019-04-30

Abstract excerpt

The acidity-triggered rational membrane (ATRAM) peptide was designed to target acidic diseases such as cancer. An acidic extracellular medium, such as that found in aggressive tumors, drives the protonation of the glutamic acids in ATRAM, leading to the membrane translocation of its C-terminus and the formation of a transmembrane helix. Compared to healthy cells, cancerous cells often increase exposure of the nega...

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Literature Corpus work: 2b47037e-6e6a-55c7-b2db-780727aac4f5
DOI: 10.1101/623967

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