Article
Covariate adjusted inference of parent-of-origin effects using case-control mother-child paired multilocus genotype data.
Genetic epidemiology - 1 Dec 2021
Zhang Kai, Zhang Hong, Hochner Hagit, Chen Jinbo
Abstract excerpt
It is of great interest to identify parent-of-origin effects (POEs) since POEs play an important role in many human heritable disorders and human early life growth and development. POE is sometimes referred to as imprinting effect in the literature. Compared with the standard logistic regression analyses, retrospective likelihood-based statistical methods are more powerful in identifying POEs when data are...
Topics
- Case-Control Studies
- Cohort Studies
- Female
- Genotype
- Humans
- Likelihood Functions
- Models, Genetic
- Mother-Child Relations
- Pregnancy
- Retrospective Studies