Article
A multi-locus likelihood method for assessing parent-of-origin effects using case-control mother-child pairs.
Genetic epidemiology - 1 Feb 2013
Lin Dongyu, Weinberg Clarice R, Feng Rui, Hochner Hagit, Chen Jinbo
Abstract excerpt
Parent-of-origin effects have been pointed out to be one plausible source of the heritability that was unexplained by genome-wide association studies. Here, we consider a case-control mother-child pair design for studying parent-of-origin effects of offspring genes on neonatal/early-life disorders or pregnancy-related conditions. In contrast to the standard case-control design, the case-control mother-child pair...
Topics
- Algorithms
- Body Mass Index
- Case-Control Studies
- Female
- Haplotypes
- Heat-Shock Proteins
- Humans
- Infant, Low Birth Weight
- Infant, Newborn
- Israel
- Likelihood Functions