Article
Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions.
European journal of human genetics : EJHG - 1 May 2020
Granot-Hershkovitz Einat, Wu Peitao, Karasik David, Peter Inga, Peloso Gina M, Levy Daniel, Vasan Ramachandran S, Adrienne Cupples L, Liu Ching-Ti, Meigs James B, Siscovick David S, Dupuis Josée, Friedlander Yechiel, Hochner Hagit
Abstract excerpt
Cardiometabolic traits pose a major global public health burden. Large-scale genome-wide association studies (GWAS) have identified multiple loci accounting for up to 30% of the genetic variance in complex traits such as cardiometabolic traits. However, the contribution of parent-of-origin effects (POEs) to complex traits has been largely ignored in GWAS. Family-based studies enable the assessment of POEs in...
Topics
- Body Size
- Female
- Genomic Imprinting
- Humans
- Male
- Maternal Inheritance
- Metabolic Syndrome
- Paternal Inheritance
- Pedigree
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci