Article
A model for family-based case-control studies of genetic imprinting and epistasis.
Briefings in bioinformatics - 1 Nov 2014
Li Xin, Sui Yihan, Liu Tian, Wang Jianxin, Li Yongci, Lin Zhenwu, Hegarty John, Koltun Walter A, Wang Zuoheng, Wu Rongling
Abstract excerpt
Genetic imprinting, or called the parent-of-origin effect, has been recognized to play an important role in the formation and pathogenesis of human diseases. Although the epigenetic mechanisms that establish genetic imprinting have been a focus of many genetic studies, our knowledge about the number of imprinting genes and their chromosomal locations and interactions with other genes is still scarce, limiting...
Topics
- Case-Control Studies
- Computational Biology
- Computer Simulation
- Databases, Genetic
- Epistasis, Genetic
- Female
- Genomic Imprinting
- Humans
- Inflammatory Bowel Diseases
- Male
- Models, Genetic
- Models, Statistical
- Polymorphism, Single Nucleotide