Article
Investigation of maternal effects, maternal-fetal interactions and parent-of-origin effects (imprinting), using mothers and their offspring.
Genetic epidemiology - 1 Jan 2011
Ainsworth Holly F, Unwin Jennifer, Jamison Deborah L, Cordell Heather J
Abstract excerpt
Many complex genetic effects, including epigenetic effects, may be expected to operate via mechanisms in the inter-uterine environment. A popular design for the investigation of such effects, including effects of parent-of-origin (imprinting), maternal genotype, and maternal-fetal genotype interactions, is to collect DNA from affected offspring and their mothers (case/mother duos) and to compare with an...
Topics
- Case-Control Studies
- Computer Simulation
- Data Interpretation, Statistical
- Epigenomics
- Female
- Fetal Development
- Genomic Imprinting
- Genotype
- Humans
- Linear Models
- Maternal-Fetal Exchange
- Models, Statistical
- Parents
- Pregnancy