Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2021

Fraszczak Jennifer, Arman Kaifee Mohammad, Lacroix Marion, Vadnais Charles, Gaboury Louis, Möröy Tarik

Abstract excerpt

GFI1 is a DNA-binding transcription factor that regulates hematopoiesis by repressing target genes through its association with complexes containing histone demethylases such as KDM1A (LSD1) and histone deacetylases (HDACs). To study the consequences of the disruption of the complex between GFI1 and histone-modifying enzymes, we have used knock-in mice harboring a P2A mutation in GFI1 coding region that renders...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Histone Demethylases

Share to Histones

Share to Macrophages

Share to Mutant Proteins

Share to Systemic Inflammatory Response Syndrome

Source

Identifiers

PMID: 34408010
DOI: 10.4049/jimmunol.2001146

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe Inflammatory Reactions in Mice Expressing a GFI1P2A Mutant Defective in Binding to the Histone Demethylase KDM1A (LSD1).PMID 34408010Read ↗

The GFI1 Gene Family: Evolution, Structure, and Its Role in Immune ResponsesSemantic proximity Read ↗

Gfi-1 Oncoproteins in HematopoiesisSemantic proximity Read ↗

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in miceSemantic proximity Read ↗

Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development.Semantic proximity Read ↗

Role of GFI1 in Epigenetic Regulation of MDS and AML Pathogenesis: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Lsd1 as a therapeutic target in Gfi1-activated medulloblastomaSemantic proximity Read ↗

Gfi1–cells and circuits: unraveling transcriptional networks of development and diseaseSemantic proximity Read ↗

Transcription factor Gfi1 restricts B cell-mediated autoimmunity.Semantic proximity Read ↗

Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development.Semantic proximity Read ↗

Transcription Factor GFI1B in Health and DiseaseSemantic proximity Read ↗

Deletion of Gpatch2 does not alter Tnf expression in miceSemantic proximity Read ↗

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.