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Article

BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation.

The Journal of cell biology - 14 Sept 2015

Fulgenzi Gianluca, Tomassoni-Ardori Francesco, Babini Lucia, Becker Jodi, Barrick Colleen, Puverel Sandrine, Tessarollo Lino

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) is critical for mammalian development and plasticity of neuronal circuitries affecting memory, mood, anxiety, pain sensitivity, and energy homeostasis. Here we report a novel unexpected role of BDNF in regulating the cardiac contraction force independent of the nervous system innervation. This function is mediated by the truncated TrkB.T1 receptor expressed in...

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Identifiers

PMID: 26347138
DOI: 10.1083/jcb.201502100
PMCID: PMC4576863

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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