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Article

Brain-derived neurotrophic factor (BDNF)-induced mitochondrial motility arrest and presynaptic docking contribute to BDNF-enhanced synaptic transmission.

The Journal of biological chemistry - 17 Jan 2014

Su Bo, Ji Yun-Song, Sun Xu-lu, Liu Xiang-Hua, Chen Zhe-Yu

Abstract excerpt

Appropriate mitochondrial transport and distribution are essential for neurons because of the high energy and Ca(2+) buffering requirements at synapses. Brain-derived neurotrophic factor (BDNF) plays an essential role in regulating synaptic transmission and plasticity. However, whether and how BDNF can regulate mitochondrial transport and distribution are still unclear. Here, we find that in cultured hippocampal...

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Identifiers

PMID: 24302729
DOI: 10.1074/jbc.M113.526129
PMCID: PMC3894308

Genes

BDNF
TRPC3
TRPC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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