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Article

Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.

Biological psychiatry - 1 Jun 2012

Liu Rong-Jian, Lee Francis S, Li Xiao-Yuan, Bambico Francis, Duman Ronald S, Aghajanian George K

Abstract excerpt

BACKGROUND: Knock-in mice with the common human brain-derived neurotrophic factor (BDNF) Val66Met polymorphism have impaired trafficking of BDNF messenger RNA to dendrites. It was hypothesized, given evidence that local synapse formation is dependent on dendritic translation of BDNF messenger RNA, that loss-of-function Met allele mice would show synaptic deficits both at baseline and in response to ketamine, an...

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Identifiers

PMID: 22036038
DOI: 10.1016/j.biopsych.2011.09.030
PMCID: PMC3290730

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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