Article
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus.
Neurobiology of learning and memory - 1 Jan 2020
Wu Chunhui, Wang Yu, He Yang, Wu Song, Xie Zhifei, Zhang Jian, Shen Jingshan, Wang Zhen, He Ling
Abstract excerpt
Clinical and preclinical researches have shown that sub-anesthetic ketamine elicits sustained antidepressant effects for up to 1-2 weeks. Pharmacokinetics studies (t1/2 = 23 min) in mice showed no ketamine residue at 24 h after sub-anesthetic or anesthetic ketamine administration. Therefore, this study aims to reveal the mechanism underlying these different biological functions at 24 h after sub-anesthetic and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.