Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.

Nature communications - 16 Mar 2018

Fera Daniela, Lee Matthew S, Wiehe Kevin, Meyerhoff R Ryan, Piai Alessandro, Bonsignori Mattia, Aussedat Baptiste, Walkowicz William E, Ton Therese, Zhou Jeffrey O, Danishefsky Samuel, Haynes Barton F, Harrison Stephen C

Abstract excerpt

HIV-1 envelope (Env) mimetics are candidate components of prophylactic vaccines and potential therapeutics. Here we use a synthetic V3-glycopeptide ("Man9-V3") for structural studies of an HIV Env third variable loop (V3)-glycan directed, broadly neutralizing antibody (bnAb) lineage ("DH270"), to visualize the epitope on Env and to study how affinity maturation of the lineage proceeded. Unlike many previous V3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitope Mapping

Share to Epitopes

Share to Gene Products, env

Share to HIV Antibodies

Share to HIV Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 29549260
DOI: 10.1038/s41467-018-03565-6
PMCID: PMC5856820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.PMID 29549260Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.Semantic proximity Read ↗

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutationsSemantic proximity Read ↗

Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus MacaqueSemantic proximity Read ↗

Functional development of a V3/glycan-specific broadly neutralizing antibody isolated from a case of HIV superinfection.Semantic proximity Read ↗

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelopeSemantic proximity Read ↗

Identification of a broad and potent V3 glycan site bNAb targeting an N332 <sub>gp120</sub> glycan-independent epitopeSemantic proximity Read ↗

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodiesSemantic proximity Read ↗

Rapid and Focused Maturation of a VRC01-Class HIV Broadly Neutralizing Antibody Lineage Involves Both Binding and Accommodation of the N276-GlycanSemantic proximity Read ↗

Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.Semantic proximity Read ↗

Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine DesignSemantic proximity Read ↗

Functional development of a V3-specific broadly neutralizing antibody isolated from a case of HIV superinfectionSemantic proximity Read ↗

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.