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Article

Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype.

NeuroImage - 15 Nov 2021

Furman Daniella J, Pappas Ioannis, White Robert L, Kayser Andrew S, D'Esposito Mark

Abstract excerpt

The cognitive effects of pharmacologically enhancing cortical dopamine (DA) tone are variable across healthy human adults. It has been postulated that individual differences in drug responses are linked to baseline cortical DA activity according to an inverted-U-shaped function. To better understand the effect of divergent starting points along this curve on DA drug responses, researchers have leveraged a common...

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Identifiers

PMID: 34390874
DOI: 10.1016/j.neuroimage.2021.118472

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