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Article

COMT genotype and resting brain perfusion in children.

NeuroImage - 15 Oct 2009

Thomason Moriah E, Waugh Christian E, Glover Gary H, Gotlib Ian H

Abstract excerpt

Levels of extra-synaptic dopamine in the brain vary as a function of polymorphisms at the val158met locus of the catechol-O-methyltransferase (COMT) gene. In vivo studies of this polymorphism in the human brain have typically measured patterns of neural activation during dopamine-mediated tasks in adults. This study is the first to investigate the effects of COMT on brain physiology during rest and in children....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19500679
DOI: 10.1016/j.neuroimage.2009.05.076
PMCID: PMC2735191

Genes

COMT
ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT genotype and resting brain perfusion in children.PMID 19500679Read ↗

Enhancing dopamine tone modulates global and local cortical perfusion as a function of COMT val158met genotype.Semantic proximity Read ↗

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COMT val158met genotype affects recruitment of neural mechanisms supporting fluid intelligence.Semantic proximity Read ↗

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Effect of the COMT Val158Met genotype on lateral prefrontal activations in young children.Semantic proximity Read ↗

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