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Article

Tolcapone improves cognition and cortical information processing in normal human subjects.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2007

Apud José A, Mattay Venkata, Chen Jingshan, Kolachana Bhaskar S, Callicott Joseph H, Rasetti Roberta, Alce Guilna, Iudicello Jennifer E, Akbar Natkai, Egan Michael F, Goldberg Terry E, Weinberger Daniel R

Abstract excerpt

Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory. Efforts to enhance prefrontal-related cognition, which have focused on catecholaminergic stimulant drugs, have been unsatisfactory. Recently, the demonstration that a functional polymorphism in the catecholamine-O-methyltransferase (COMT) gene impacts prefrontal cognition raises the...

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Identifiers

PMID: 17063156
DOI: 10.1038/sj.npp.1301227

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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