Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression.

Epigenetics - 1 Jan 2018

Belot Marie-Pierre, Castell Anne-Laure, Le Fur Sophie, Bougnères Pierre

Abstract excerpt

IL2RA, a subunit of the high affinity receptor for interleukin-2 (IL2), plays a crucial role in immune homeostasis. Notably, IL2RA expression is induced in CD4+ T cells in response to various stimuli and is constitutive in regulatory T cells (Tregs). We selected for our study 18 CpGs located within cognate regulatory regions of the IL2RA locus and characterized their methylation in naive, regulatory, and memory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to CD4-Positive T-Lymphocytes
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Interleukin-2 Receptor alpha Subunit

Share to Lymphocyte Activation

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 30096258
DOI: 10.1080/15592294.2018.1469893
PMCID: PMC6140818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic demethylation of the IL2RA promoter during in vitro CD4+ T cell activation in association with IL2RA expression.PMID 30096258Read ↗

Differential CpG DNA methylation in peripheral naïve CD4+ T-cells in early rheumatoid arthritis patientsSemantic proximity Read ↗

Multiple single nucleotide polymorphisms in the first intron of the IL2RA gene affect transcription factor binding and enhancer activity.Semantic proximity Read ↗

IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8+ T Cells.Semantic proximity Read ↗

CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset.Semantic proximity Read ↗

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiationSemantic proximity Read ↗

DNA Methylation Changes at Human Th2 Cytokine Genes Coincide with DNase I Hypersensitive Site Formation During CD4+ T Cell DifferentiationSemantic proximity Read ↗

Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathySemantic proximity Read ↗

Non-linear Age-related Change in Human Interleukin-11 and the receptor subunit alpha DNA MethylationSemantic proximity Read ↗

A rare <i>IL2RA</i> haplotype identifies SNP rs61839660 as causal for autoimmunitySemantic proximity Read ↗

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells.Semantic proximity Read ↗

In-vitro characterization of novel and functional regulatory SNPs in the promoter region of IL2 and IL2R alpha in a Gabonese population.Semantic proximity Read ↗

Hypermethylation of IL‐10 gene is responsible for its low mRNA expression in Behçet's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.