Article
Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients.
Journal of autoimmunity - 1 Mar 2009
Akkad D A, Hoffjan S, Petrasch-Parwez E, Beygo J, Gold R, Epplen J T
Abstract excerpt
Variation in the genes encoding the interleukin (IL) 7 and IL2 receptor alpha chains (IL7RA, IL2RA) was recently found associated with multiple sclerosis (MS). We evaluated the role of these two genes in a large German MS case-control cohort. Five single nucleotide polymorphisms (SNPs) in IL7RA and four in IL2RA were genotyped in 1319 MS patients and 908 controls by means of restriction enzyme digestion or TaqMan...
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