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Article

A cis-acting regulatory variant in the IL2RA locus.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2009

Qu Hui-Qi, Verlaan Dominique J, Ge Bing, Lu Yang, Lam Kevin C L, Grabs Rosemarie, Harmsen Eef, Hudson Thomas J, Hakonarson Hakon, Pastinen Tomi, Polychronakos Constantin

Abstract excerpt

The mechanism for the association of type 1 diabetes (T1D) with IL2RA remains to be clarified. Neither of the two distinct, transmission-disequilibrium confirmed loci mapping to this gene can be explained by a coding variant. An effect on the levels of the soluble protein product sIL-2RA has been reported but its cause and relationship to disease risk is not clear. To look for an allelic effect on IL2RA...

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Share to Alleles
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Interleukin-2 Receptor alpha Subunit

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 19794070
DOI: 10.4049/jimmunol.0901337

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