Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression.

Scientific reports - 12 Aug 2021

Shiraishi Wataru, Yamasaki Ryo, Hashimoto Yu, Ko Senri, Kobayakawa Yuko, Isobe Noriko, Matsushita Takuya, Kira Jun-Ichi

Abstract excerpt

Macrophages expressing C-C chemokine receptor type 2 (CCR2) infiltrate the central and peripheral neural tissues of amyotrophic lateral sclerosis (ALS) patients. To identify the functional role of CCR2+ macrophages in the pathomechanisms of ALS, we used an ALS animal model, mutant Cu/Zn superoxide dismutase 1G93A (mSOD1)-transgenic (Tg) mice. To clarify the CCR2 function in the model, we generated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CX3C Chemokine Receptor 1
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Motor Neuron Disease

Share to Peripheral Nerves

Share to Receptors, CCR2

Share to Spinal Cord

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 34385589
DOI: 10.1038/s41598-021-96064-6
PMCID: PMC8360983

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clearance of peripheral nerve misfolded mutant protein by infiltrated macrophages correlates with motor neuron disease progression.PMID 34385589Read ↗

Downregulated Glia Interplay and Increased miRNA-155 as Promising Markers to Track ALS at an Early Stage.Semantic proximity Read ↗

Boosting The Peripheral Immune Response in the Skeletal Muscles Improved Motor Function in ALS Transgenic MiceSemantic proximity Read ↗

Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in miceSemantic proximity Read ↗

Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.Semantic proximity Read ↗

Immune response in peripheral axons delays disease progression in SOD1G93A mice.Semantic proximity Read ↗

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.Semantic proximity Read ↗

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's DiseaseSemantic proximity Read ↗

Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS.Semantic proximity Read ↗

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.Semantic proximity Read ↗

Plasma miRNA-214 is a predictive candidate biomarker of progression speed in patients with ALSSemantic proximity Read ↗

Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral SclerosisSemantic proximity Read ↗

PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.