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Article

Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model.

Human molecular genetics - 1 Oct 2004

Tateno Minako, Sadakata Hisako, Tanaka Mika, Itohara Shigeyoshi, Shin Ryong-Moon, Miura Masami, Masuda Masao, Aosaki Toshihiko, Urushitani Makoto, Misawa Hidemi, Takahashi Ryosuke

Abstract excerpt

Mutant Cu/Zn-superoxide dismutase (SOD1) protein aggregation has been suggested as responsible for amyotrophic lateral sclerosis (ALS), although the operative mediating factors are as yet unestablished. To evaluate the contribution of motoneuronal Ca2+-permeable (GluR2 subunit-lacking) alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors to SOD1-related motoneuronal death, we...

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Source

Identifiers

PMID: 15294873
DOI: 10.1093/hmg/ddh246

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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