Article

PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse model

2026-06-03

Abstract excerpt

<h4>Background</h4> Dysregulated peptidyl deiminase 2 (PAD2) and aberrant protein citrullination (PC), a posttranslational modification (PTM), are involved in various inflammatory and neurodegenerative diseases. We previously showed in transgenic mice and postmortem human tissues that PC and PAD2 are altered in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by motor neurons loss, p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 88334d44-629a-554a-84d7-486f307dd3b8
DOI: 10.64898/2026.05.30.729013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse modelDOI 10.64898/2026.05.30.729013Read

Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative DiseasesSemantic proximity Read

PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelinationSemantic proximity Read

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.Semantic proximity Read

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosisSemantic proximity Read

Probing tau citrullination in Alzheimer’s disease brains and mouse models of tauopathySemantic proximity Read

<i>Atxn2</i> -CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppressionSemantic proximity Read

A quantitative and site-specific atlas of the in vivo citrullinome reveals widespread existence of citrullinationSemantic proximity Read

Peptidyl Arginine Deiminases in Chronic Diseases: A Focus on Rheumatoid Arthritis and Interstitial Lung DiseaseSemantic proximity Read

The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple SclerosisSemantic proximity Read

Citrullination and the protein code: crosstalk between post-translational modifications in cancerSemantic proximity Read

Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathiesSemantic proximity Read

Peptidylarginine deiminase 4 and citrullination in health and disease.Semantic proximity Read