Article
Immune response in peripheral axons delays disease progression in SOD1G93A mice.
Journal of neuroinflammation - 7 Oct 2016
Nardo Giovanni, Trolese Maria Chiara, de Vito Giuseppe, Cecchi Roberta, Riva Nilo, Dina Giorgia, Heath Paul R, Quattrini Angelo, Shaw Pamela J, Piazza Vincenzo, Bendotti Caterina
Abstract excerpt
BACKGROUND: Increasing evidence suggests that the immune system has a beneficial role in the progression of amyotrophic lateral sclerosis (ALS) although the mechanism remains unclear. Recently, we demonstrated that motor neurons (MNs) of C57SOD1G93A mice with slow disease progression activate molecules classically involved in the cross-talk with the immune system. This happens a lot less in 129SvSOD1G93A mice...
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