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Article

Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2016

Leyton-Jaimes Marcel F, Benaim Clara, Abu-Hamad Salah, Kahn Joy, Guetta Amos, Bucala Richard, Israelson Adrian

Abstract excerpt

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease characterized by the loss of upper and lower motor neurons in the brain and spinal cord. It has been suggested that the toxicity of mutant SOD1 results from its misfolding and accumulation on the cytoplasmic faces of intracellular organelles, including the mitochondria and endoplasmic reticulum...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27551074
DOI: 10.1073/pnas.1604600113
PMCID: PMC5018779

Genes

SOD1
MIF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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