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Article

Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.

Neuron - 8 Apr 2015

Israelson Adrian, Ditsworth Dara, Sun Shuying, Song SungWon, Liang Jason, Hruska-Plochan Marian, McAlonis-Downes Melissa, Abu-Hamad Salah, Zoltsman Guy, Shani Tom, Maldonado Marcus, Bui Anh, Navarro Michael, Zhou Huilin, Marsala Martin, Kaspar Brian K, Da Cruz Sandrine, Cleveland Don W

Abstract excerpt

Mutations in superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by loss of motor neurons and accompanied by accumulation of misfolded SOD1 onto the cytoplasmic faces of intracellular organelles, including mitochondria and the endoplasmic reticulum (ER). Using inhibition of misfolded SOD1 deposition onto mitochondria as an assay, a chaperone activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25801706
DOI: 10.1016/j.neuron.2015.02.034
PMCID: PMC4393372

Genes

SOD1
MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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