Article
PHF6 mutations in T-cell acute lymphoblastic leukemia.
Nature genetics - 1 Apr 2010
Van Vlierberghe Pieter, Palomero Teresa, Khiabanian Hossein, Van der Meulen Joni, Castillo Mireia, Van Roy Nadine, De Moerloose Barbara, Philippé Jan, González-García Sara, Toribio María L, Taghon Tom, Zuurbier Linda, Cauwelier Barbara, Harrison Christine J, Schwab Claire, Pisecker Markus, Strehl Sabine, Langerak Anton W, Gecz Jozef, Sonneveld Edwin, Pieters Rob, Paietta Elisabeth, Rowe Jacob M, Wiernik Peter H, Benoit Yves, Soulier Jean, Poppe Bruce, Yao Xiaopan, Cordon-Cardo Carlos, Meijerink Jules, Rabadan Raul, Speleman Frank, Ferrando Adolfo
Abstract excerpt
Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with an increased incidence in males. In this study, we report the identification of inactivating mutations and deletions in the X-linked plant homeodomain finger 6 (PHF6) gene in 16% of pediatric and 38% of adult primary...
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