Article
Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.
Haematologica - 1 Dec 2011
Wang Qian, Qiu Huiying, Jiang Hui, Wu Lili, Dong Shasha, Pan Jinlan, Wang Wenjuan, Ping Nana, Xia Jing, Sun Aining, Wu Depei, Xue Yongquan, Drexler Hans G, Macleod Roderick A F, Chen Suning
Abstract excerpt
BACKGROUND: Mutations in the PHF6 gene were recently described in patients with T-cell acute lymphoblastic leukemia and in those with acute myeloid leukemia. The present study was designed to determine the prevalence of PHF6 gene alterations in T-cell acute lymphoblastic leukemia. DESIGN AND METHODS: We analyzed the incidence and prognostic value of PHF6 mutations in 96 Chinese patients with T-cell acute...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.