Article
PHF6 mutations in adult acute myeloid leukemia.
Leukemia - 1 Jan 2011
Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat C V, Balbin M, Nicolas C, Payer A R, Fernandez H F, Tallman M S, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, Cools J, Levine R, Ferrando A
Abstract excerpt
Loss of function mutations and deletions encompassing the plant homeodomain finger 6 (PHF6) gene are present in about 20% of T-cell acute lymphoblastic leukemias (ALLs). Here, we report the identification of recurrent mutations in PHF6 in 10/353 adult acute myeloid leukemias (AMLs). Genetic lesions in PHF6 found in AMLs are frameshift and nonsense mutations distributed through the gene or point mutations...
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