Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PHF6 mutations in chronic myelomonocytic leukemia identify a unique subset of patients with distinct phenotype and superior prognosis.

American journal of hematology - 1 Dec 2024

Tefferi Ayalew, Fathima Saubia, Alsugair Ali Khalid A, Aperna Fnu, Natu Anuya, Abdelmagid Maymona G, Csizmar Clifford M, Gurney Mark, Lasho Terra L, Finke Christy M, Mangaonkar Abhishek A, Al-Kali Aref, Pardanani Animesh, Reichard Kaaren K, He Rong, Gangat Naseema, Patnaik Mrinal M

Abstract excerpt

The current study was inspired by observations from exploratory analyses of an institutional cohort with chronic myelomonocytic leukemia (CMML; N = 398) that revealed no instances of blast transformation in the seven patients with plant homeodomain finger protein 6 (PHF6) mutation (PHF6MUT). A subsequent Mayo Clinic enterprise-wide database search identified 28 more cases with PHF6MUT. Compared with their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to Dioxygenases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3A

Share to Leukemia, Myelomonocytic, Chronic

Share to Proto-Oncogene Proteins

Share to Serine-Arginine Splicing Factors

Share to Splicing Factor U2AF

Source

Identifiers

PMID: 39329442
DOI: 10.1002/ajh.27492

Genes

PHF6
CBL
RUNX1
SRSF2
TET2
U2AF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PHF6 mutations in chronic myelomonocytic leukemia identify a unique subset of patients with distinct phenotype and superior prognosis.PMID 39329442Read ↗

PHF6 Mutations in Hematologic MalignanciesSemantic proximity Read ↗

Clinical Characteristics, Gene Mutation Profiles and Prognosis of Patients With Acute Myeloid Leukemia Carrying PHF6 Mutations.Semantic proximity Read ↗

Chronic Myelomonocytic Leukemia: a Genetic and Clinical Update.Semantic proximity Read ↗

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.Semantic proximity Read ↗

PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiationSemantic proximity Read ↗

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.Semantic proximity Read ↗

The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature.Semantic proximity Read ↗

BLAST: a globally applicable and molecularly versatile survival model for chronic myelomonocytic leukemia.Semantic proximity Read ↗

Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia.Semantic proximity Read ↗

PHF6 mutations in adult acute myeloid leukemia.Semantic proximity Read ↗

PHF6 mutations in myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemiaSemantic proximity Read ↗

Phf6-null hematopoietic stem cells have enhanced self-renewal capacity and oncogenic potentialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.