Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical Characteristics, Gene Mutation Profiles and Prognosis of Patients With Acute Myeloid Leukemia Carrying PHF6 Mutations.

Cancer medicine - 1 May 2026

Wang Dongmei, Pan Hanzhang, Wang Yungui, Xu Huan, Liu Lin, Xu Yuting, Tong Hongyan

Abstract excerpt

BACKGROUND: Plant Homeodomain Finger Protein 6 (PHF6) gene mutations are rare in acute myeloid leukemia (AML), with unclear mechanisms and uncertain prognostic value. They may compromise risk stratification and treatment decisions. This study analyzed clinical features and survival outcomes in PHF6-mutated AML patients, evaluating the impact of allogeneic hematopoietic stem cell transplantation (HSCT) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Core Binding Factor Alpha 2 Subunit
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cell Transplantation

Share to Isocitrate Dehydrogenase

Share to Kaplan-Meier Estimate

Share to Leukemia, Myeloid, Acute

Share to Progression-Free Survival

Share to Transplantation, Homologous

Source

Open in PubMed Open full text

Identifiers

PMID: 42087483
DOI: 10.1002/cam4.71902
PMCID: PMC13144755

Genes

PHF6
EFS
IDH1
IDH2
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical Characteristics, Gene Mutation Profiles and Prognosis of Patients With Acute Myeloid Leukemia Carrying PHF6 Mutations.PMID 42087483Read ↗

PHF6 mutation is associated with poor outcome in acute myeloid leukaemia.Semantic proximity Read ↗

The effects of the PHF6 gene mutation on myeloid neoplasms. A single-center cohort underpinned by a systematic review of literature.Semantic proximity Read ↗

PHF6 mutations in adult acute myeloid leukemia.Semantic proximity Read ↗

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting.Semantic proximity Read ↗

PHF6 mutations in chronic myelomonocytic leukemia identify a unique subset of patients with distinct phenotype and superior prognosis.Semantic proximity Read ↗

PHF6 Mutations in Hematologic MalignanciesSemantic proximity Read ↗

The clinical consequences of the PHF6 gene mutation in myeloid neoplasms. A Spanish cohort underpinned by a systematic review of literatureSemantic proximity Read ↗

PHF6 maintains acute myeloid leukemia via regulating NF-kB signaling pathwaySemantic proximity Read ↗

PHF6 maintains acute myeloid leukemia via regulating NF-κB signaling pathwaySemantic proximity Read ↗

Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.Semantic proximity Read ↗

Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma.Semantic proximity Read ↗

Leukemia-mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemnessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.