Article
Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r.
BMC bioinformatics - 28 Oct 2022
Boudry Augustin, Darmon Sasha, Duployez Nicolas, Figeac Martin, Geffroy Sandrine, Bucci Maxime, Celli-Lebras Karine, Duchmann Matthieu, Joudinaud Romane, Fenwarth Laurène, Nibourel Olivier, Goursaud Laure, Itzykson Raphael, Dombret Hervé, Hunault Mathilde, Preudhomme Claude, Salson Mikaël
Abstract excerpt
BACKGROUND: Internal tandem duplications in the FLT3 gene, termed FLT3-ITDs, are useful molecular markers in acute myeloid leukemia (AML) for patient risk stratification and follow-up. FLT3-ITDs are increasingly screened through high-throughput sequencing (HTS) raising the need for robust and efficient algorithms. We developed a new algorithm, which performs no alignment and uses little resources, to identify and...
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