Article

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r

2022-06-29

Abstract excerpt

<h4>Background</h4> Internal tandem duplications in the FLT3 gene, termed FLT3 -ITDs, are useful molecular markers in acute myeloid leukemia (AML) for patient risk stratification and follow-up. FLT3 -ITDs are increasingly screened through high-throughput sequencing (HTS) raising the need for robust and efficient algorithms. We developed a new algorithm, which performs no alignment and uses little resources, to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 226cd371-82eb-58b2-9558-13bbe5861292
DOI: 10.1101/2022.06.27.496265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3rDOI 10.1101/2022.06.27.496265Read

Frugal alignment-free identification of FLT3-internal tandem duplications with FiLT3r.Semantic proximity Read

ITDetect: a method to detect internal tandem duplication of FMS-like tyrosine kinase (FLT3) from next-generation sequencing data with high sensitivity and clinical application.Semantic proximity Read

Accurate Detection and Quantification of FLT3 Internal Tandem Duplications in Clinical Hybrid Capture Next-Generation Sequencing Data.Semantic proximity Read

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia.Semantic proximity Read

Revealing molecular architecture of FLT3 internal tandem duplication: Development and clinical validation of a web-based application to generate accurate nomenclature.Semantic proximity Read

ITD assembler: an algorithm for internal tandem duplication discovery from short-read sequencing data.Semantic proximity Read

ScanITD: Detecting internal tandem duplication with robust variant allele frequency estimation.Semantic proximity Read

Comprehensive review and evaluation of computational methods for identifying FLT3-internal tandem duplication in acute myeloid leukaemia.Semantic proximity Read

[Application of High-throughput Sequencing in Acute Myeloid Leukemia Patients with Positive FLT3-ITD].Semantic proximity Read

Genomon ITDetector: a tool for somatic internal tandem duplication detection from cancer genome sequencing data.Semantic proximity Read

Hybridization capture-based next generation sequencing reliably detects FLT3 mutations and classifies FLT3-internal tandem duplication allelic ratio in acute myeloid leukemia: a comparative study to standard fragment analysisSemantic proximity Read

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.Semantic proximity Read