Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.

doi:10.1038/s41467-021-24735-z

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Article

Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles.

Nature communications - 6 Aug 2021

Zhang Jiyuan, Guan Xin, Shah Kunal, Yan Jiusheng

Abstract excerpt

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+-mobilizing second messenger which uniquely mobilizes Ca2+ from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the endolysosomal two-pore channel (TPC1 or TPC2) in NAADP signaling, we performed affinity purification and quantitative proteomic analysis of the...

Topics

Animals
Calcium
Calcium Channels
Cell Line
Circadian Rhythm Signaling Peptides and Proteins
Endosomes
Fibroblasts
HEK293 Cells
Humans
Lysosomes
Mice
Mutation
NADP
Porins
Proteomics

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Identifiers

PMID: 34362892
DOI: 10.1038/s41467-021-24735-z
PMCID: PMC8346516

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