Article

Nucleus-Tethered Mitochondria are essential for Ca²⁺ homeostasis

2025-03-18

Abstract excerpt

<title>Abstract</title> <p>Mitochondria form dynamic membrane contact sites (MCSs) with the surrounding organelles, including the nucleus, which we termed ‘nucleus-associated mitochondria’ (NAM). In this manuscript, we report that the stoichiometry of the NAM-forming molecule TSPO is modified in neurodegeneration diseases, and the nucleus-based component of the chromatin- and lamin-binding protein thymopoietin (T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f57f469b-74c8-52e3-a61d-0c4da1a75385
DOI: 10.21203/rs.3.rs-6015469/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nucleus-Tethered Mitochondria are essential for Ca²⁺ homeostasisDOI 10.21203/rs.3.rs-6015469/v1Read

Timeline: Mitochondria.Semantic proximity Read

PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s DiseaseSemantic proximity Read

Mitochondrial Ca2+ and neurodegenerationSemantic proximity Read

Mitocellular communication: Shaping health and diseaseSemantic proximity Read

Mitochondria-Associated Membranes As Networking Platforms and Regulators of Cancer Cell FateSemantic proximity Read

Miro proteins connect mitochondrial function and intercellular transportSemantic proximity Read

[Structural organization and function of nuclear envelope].Semantic proximity Read

Beyond Static Tethering at Membrane Contact Sites: Structural Dynamics and Functional Implications of VAP ProteinsSemantic proximity Read

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyondSemantic proximity Read

Miro1 mutations disrupt cellular calcium homeostasis via dysregulation of mitochondria-ER-contact-sites, rendering iPSC-derived neurons more susceptible to lipid peroxidation.Semantic proximity Read

Mitochondria and its epigenetic dynamics: Insight into synaptic regulation and synaptopathiesSemantic proximity Read

Mitochondria at the SynapseSemantic proximity Read