Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

doi:10.1074/jbc.C110.143123

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Article

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

The Journal of biological chemistry - 9 Jul 2010

Schieder Michael, Rötzer Katrin, Brüggemann Andrea, Biel Martin, Wahl-Schott Christian A

Abstract excerpt

Two-pore channels (TPCNs) have been proposed to form lysosomal Ca(2+) release channels that are activated by nicotinic acid adenine dinucleotide phosphate. Here, we employ a glass chip-based method to record for the first time nicotinic acid adenine dinucleotide phosphate -dependent currents through a two-pore channel (TPCN2) from intact lysosomes. We show that TPCN2 is a highly selective Ca(2+) channel that is...

Topics

Animals
Calcium
Calcium Channels
Calcium Signaling
Cell Line
Electrophysiology
Green Fluorescent Proteins
Humans
Ion Channel Gating
Lysosomes
Mice
Models, Biological
Mutagenesis, Site-Directed
Mutation
beta-N-Acetylhexosaminidases

Source

Open in PubMed Open full text

Identifiers

PMID: 20495006
DOI: 10.1074/jbc.C110.143123
PMCID: PMC2898409

Genes

TPCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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