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Article

Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.

The Journal of biological chemistry - 9 Jul 2010

Schieder Michael, Rötzer Katrin, Brüggemann Andrea, Biel Martin, Wahl-Schott Christian A

Abstract excerpt

Two-pore channels (TPCNs) have been proposed to form lysosomal Ca(2+) release channels that are activated by nicotinic acid adenine dinucleotide phosphate. Here, we employ a glass chip-based method to record for the first time nicotinic acid adenine dinucleotide phosphate -dependent currents through a two-pore channel (TPCN2) from intact lysosomes. We show that TPCN2 is a highly selective Ca(2+) channel that is...

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Identifiers

PMID: 20495006
DOI: 10.1074/jbc.C110.143123
PMCID: PMC2898409

Genes

TPCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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