Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.

Cell calcium - 1 Dec 2017

Patel Sandip, Churamani Dev, Brailoiu Eugen

Abstract excerpt

Two-pore channels (TPCs) are two-domain members of the voltage-gated ion channel superfamily that localize to acidic organelles. Their mechanism of activation (ligands such as NAADP/PI(3,5)P2 versus voltage) and ion selectivity (Ca2+ versus Na+) is debated. Here we report that a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Arginine
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Cell Line

Share to Mutation

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 29129203
DOI: 10.1016/j.ceca.2017.09.003
PMCID: PMC5700777

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.PMID 29129203Read ↗

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling.Semantic proximity Read ↗

A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.Semantic proximity Read ↗

Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.Semantic proximity Read ↗

The S4---S5 linker - gearbox of TRP channel gating.Semantic proximity Read ↗

A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites.Semantic proximity Read ↗

Requirement of multiple protein domains and residues for gating K(ATP) channels by intracellular pH.Semantic proximity Read ↗

An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.Semantic proximity Read ↗

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation.Semantic proximity Read ↗

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels.Semantic proximity Read ↗

A conserved gating element in TRPV6 channels.Semantic proximity Read ↗

Essential role for the putative S6 inner pore region in the activation gating of the human TRPA1 channel.Semantic proximity Read ↗

The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.