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NAADP-evoked Ca2+ signals through two-pore channel-1 require arginine residues in the first S4-S5 linker.

Cell calcium - 1 Dec 2017

Patel Sandip, Churamani Dev, Brailoiu Eugen

Abstract excerpt

Two-pore channels (TPCs) are two-domain members of the voltage-gated ion channel superfamily that localize to acidic organelles. Their mechanism of activation (ligands such as NAADP/PI(3,5)P2 versus voltage) and ion selectivity (Ca2+ versus Na+) is debated. Here we report that a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth...

Topics

Amino Acid Sequence
Arginine
Calcium Channels
Calcium Signaling
Cell Line
Humans
Mutation
NADP
Structure-Activity Relationship

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29129203
DOI: 10.1016/j.ceca.2017.09.003
PMCID: PMC5700777

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