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Article

Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation.

The Journal of biological chemistry - 18 Mar 2011

Hooper Robert, Churamani Dev, Brailoiu Eugen, Taylor Colin W, Patel Sandip

Abstract excerpt

Two-pore channels (TPCs) localize to the endolysosomal system and have recently emerged as targets for the Ca(2+)-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). However, their membrane topology is unknown. Using fluorescence protease protection assays, we show that human TPC1 and TPC2 possess cytosolic N and C termini and therefore an even number of transmembrane regions....

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Identifiers

PMID: 21173144
DOI: 10.1074/jbc.M110.189985
PMCID: PMC3059026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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