Article
Molecular Dynamics Simulations in Designing DARPins as Phosphorylation-Specific Protein Binders of ERK2.
Molecules (Basel, Switzerland) - 27 Jul 2021
Gautam Vertika, Nimmanpipug Piyarat, Zain Sharifuddin Md, Rahman Noorsaadah Abd, Lee Vannajan Sanghiran
Abstract excerpt
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play key roles in promoting cell survival and proliferation through the phosphorylation of various substrates. Remarkable antitumour activity is found in many inhibitors that act upstream of the ERK pathway. However, drug-resistant tumour cells invariably emerge after their use due to the reactivation of ERK1/2 signalling. ERK1/2 inhibitors have shown...
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