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Exploring the Dynamic Interplay of Deleterious Variants on the RAF1-RAP1A Binding in Cancer: Conformational Analysis, Binding Free Energy, and Essential Dynamics.

Proteins - 1 Mar 2025

Khan Abbas, Ali Syed Shujait, Zahid Muhammad Ammar, Abdelsalam Shahenda Salah, Albekairi Noorah, Al-Zoubi Raed M, Shkoor Mohanad, Wei Dong-Qing, Agouni Abdelali

Abstract excerpt

The RAF1-RAP1A interaction activates the MAPK/ERK pathway which is very crucial in the carcinogenesis process. This protein complex influences tumor formation, proliferation, and metastasis. Understanding aberrant interactions driven by clinical mutations is vital for targeted therapies. Hence, the current study focuses on the screening of clinically reported substitutions in the RAF1 and RAP1A genes using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39498560
DOI: 10.1002/prot.26759
PMCID: PMC11809134

Genes

RAF1
RAP1A

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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