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Article

In silico identification of novel kinase inhibitors by targeting B-Raf(v660e) from natural products database.

Journal of molecular modeling - 1 Apr 2015

Wang Zi-jie, Wan Zhi-ning, Chen Xu-dong, Wu Chuan-fang, Gao Guo-long, Liu Rong, Shi Zheng, Bao Jin-ku

Abstract excerpt

The Ras/Raf/MEK/ERK (MAPK) signaling pathway has gained much attention from scientific community for therapeutic intervention in the past decades, specifically in oncology. Notably, a most prevalent B-Raf(v600e) mutant in Raf kinase family exhibits elevated kinase activity and results in constitutive activation of the MAPK pathway, thus making it a promising drug target for cancer therapy. Herein, virtual...

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PMID: 25832798
DOI: 10.1007/s00894-015-2647-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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