Thermostable designed ankyrin repeat proteins (DARPins) as building blocks for innovative drugs

Abstract excerpt

Designed Ankyrin Repeat Proteins (DARPins) are a class of antibody mimetics with a high and mostly unexplored potential in drug development. They are clinically validated and thus represent a true alternative to classical immunoglobulin formats. In contrast to immunoglobulins, they are built from solenoid protein domains comprising an N-terminal capping repeat, one or more internal repeats and a C-terminal capping...

Topics

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• Ankyrin Repeat
• Ankyrins
• Cellular transport and secretion
• Monoclonal and Polyclonal Antibodies Research
• Protein Degradation and Inhibitors
• Protein Engineering
• Protein Structure and Dynamics
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

89ba390b-1704-5cf4-9caa-8ac1745918b4

DOI

10.1101/2021.04.27.441521