Article

Revealing imatinib-kinase specificity via analyzing changes in protein dynamics and computing molecular binding affinity

2026-02-04

Abstract excerpt

Drug promiscuity is a double-edged sword where a small molecule acts on multiple biological targets to induce toxicological or therapeutic benefits. It is possible to exploit promiscuity to expand treatment options without the prohibitive costs of designing a new drug. Imatinib is a representative case, exhibiting varied affinities and inhibitions to different kinases. It binds most favorably to Abl and Kit kinase...

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Literature Corpus work: d9a47ca3-5a3b-5c7e-861c-4fb1f0e47e69
DOI: 10.64898/2026.02.02.703340

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