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Article

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation.

Journal of visualized experiments : JoVE - 20 May 2020

Tamirat Mahlet Z, Kurppa Kari J, Elenius Klaus, Johnson Mark S

Abstract excerpt

Numerous somatic mutations occurring in the epidermal growth factor receptor (EGFR) family (ErbB) of receptor tyrosine kinases (RTK) have been reported from cancer patients, although relatively few have been tested and shown to cause functional changes in ErbBs. The ErbB receptors are dimerized and activated upon ligand binding, and dynamic conformational changes of the receptors are inherent for induction of...

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PMID: 32510498
DOI: 10.3791/61125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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