Article
Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.
Journal of the National Cancer Institute - 4 Sept 2021
Du Zhaohui, Gao Guimin, Adedokun Babatunde, Ahearn Thomas, Lunetta Kathryn L, Zirpoli Gary, Troester Melissa A, Ruiz-Narváez Edward A, Haddad Stephen A, PalChoudhury Parichoy, Figueroa Jonine, John Esther M, Bernstein Leslie, Zheng Wei, Hu Jennifer J, Ziegler Regina G, Nyante Sarah, Bandera Elisa V, Ingles Sue A, Mancuso Nicholas, Press Michael F, Deming Sandra L, Rodriguez-Gil Jorge L, Yao Song, Ogundiran Temidayo O, Ojengbe Oladosu, Bolla Manjeet K, Dennis Joe, Dunning Alison M, Easton Douglas F, Michailidou Kyriaki, Pharoah Paul D P, Sandler Dale P, Taylor Jack A, Wang Qin, Weinberg Clarice R, Kitahara Cari M, Blot William, Nathanson Katherine L, Hennis Anselm, Nemesure Barbara, Ambs Stefan, Sucheston-Campbell Lara E, Bensen Jeannette T, Chanock Stephen J, Olshan Andrew F, Ambrosone Christine B, Olopade Olufunmilayo I, Yarney Joel, Awuah Baffour, Wiafe-Addai Beatrice, Conti David V, Palmer Julie R, Garcia-Closas Montserrat, Huo Dezheng, Haiman Christopher A
Abstract excerpt
BACKGROUND: Polygenic risk scores (PRSs) have been demonstrated to identify women of European, Asian, and Latino ancestry at elevated risk of developing breast cancer (BC). We evaluated the performance of existing PRSs trained in European ancestry populations among women of African ancestry. METHODS: We assembled genotype data for women of African ancestry, including 9241 case subjects and 10 193 control...
Topics
- Aged, 80 and over
- Asian People
- Black People
- Breast Neoplasms