Article
A Polygenic Risk Score for Breast Cancer in US Latinas and Latin American Women.
Journal of the National Cancer Institute - 1 Jun 2020
Shieh Yiwey, Fejerman Laura, Lott Paul C, Marker Katie, Sawyer Sarah D, Hu Donglei, Huntsman Scott, Torres Javier, Echeverry Magdalena, Bohórquez Mabel E, Martínez-Chéquer Juan Carlos, Polanco-Echeverry Guadalupe, Estrada-Flórez Ana P, Haiman Christopher A, John Esther M, Kushi Lawrence H, Torres-Mejía Gabriela, Vidaurre Tatianna, Weitzel Jeffrey N, Zambrano Sandro Casavilca, Carvajal-Carmona Luis G, Ziv Elad, Neuhausen Susan L
Abstract excerpt
BACKGROUND: More than 180 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified; these SNPs can be combined into polygenic risk scores (PRS) to predict breast cancer risk. Because most SNPs were identified in predominantly European populations, little is known about the performance of PRS in non-Europeans. We tested the performance of a 180-SNP PRS in Latinas, a...
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