Article

Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes

2021-09-19

Abstract excerpt

Mycobacterium tuberculosis remains a leading cause of infectious disease morbidity and mortality for which new drug combination therapies are needed. Combinations of respiratory inhibitors can have synergistic or synthetic lethal interactions suggesting that regimens with multiple bioenergetic inhibitors will drastically shorten treatment times. However, realizing this potential is hampered by a lack of on-target...

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Literature Corpus work: 5a8e6177-61f3-59fd-b1c1-724f6c81fe30
DOI: 10.1101/2021.09.18.460886

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