Article

Tumour evolution as ground truth for cancer whole-genome sequencing

2026-06-11

Abstract excerpt

Cancer genomes are shaped by evolutionary processes that couple mutagenesis, clonal selection, chromosomal instability, spatial growth and treatment response into structured genomic patterns, yet current benchmarking strategies largely ignore this evolutionary dependency. Here, we present SCOUT, a large-scale synthetic whole-genome sequencing resource of over 200 samples, designed for systematic benchmarking of tu...

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Literature Corpus work: ee1355be-c032-5b39-83e5-9fcd49e0cf68
DOI: 10.64898/2026.06.09.731105

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